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By J.K. Aronson (Eds.)

The unintended effects of substances Annual is designed to supply a serious and up to date account of recent details concerning adversarial drug reactions and interactions from the clinician's viewpoint. below the supervision of the sequence editors, a world group of professional authors have collected jointly the most recent info on adversarial drug results from the foreign literature. as well as describing new studies of difficult drug results, the authors have subjected these studies to serious research, environment them into context when it comes to medical relevance and significance, and cross-referring to earlier reviews the place priceless. New hostile results are pronounced and evaluated and formerly said antagonistic results are re-evaluated within the gentle of the newest info. a unique characteristic is the experiences, during which chosen antagonistic results are mentioned extensive. using the publication is greater by means of separate indexes, permitting the reader to go into the textual content by means of drug identify, antagonistic impression identify, or drug interplay. the present Annual is the 1st replace of the traditional encyclopaedic paintings during this box,'s unwanted effects of gear, Fourteenth variation, which used to be released in December 2000.

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Garon CF, Oury JH, Duran CMG. Virus-like particles in the mitral and tricuspid valves explanted from a patient treated with fenfluraminephentermine. J Heart Valve Dis 1999; 8: 232. 44. Jefferson HG, Jayne DR. Peripheral vasculopathy and nephropathy in association with phentermine. Nephrol Dial Transplant 1999; 14: 1761-3. 45. Korkmaz C, Fresko I, Yazici H. A case of systemic sclerosis that developed under dexfenfluramine use. Rheumatology 1999; 38: 379-80. 46. Aeschiimann A, Truchis P, Khan MF.

Mourand I, Ducrocq X, Lacour JC, Taillandier L, Anxionnat R, Weber M. Acute reversible cerebral arteritis associated with parenteral ephedrine use. Cerebrovasc Dis 1999; 9: 355-7. 52. Gamlin E Freeman J, Winslow L, Berridge J, Vucevic M. The hemodynamic effects of propofol in combination with ephedrine in elderly (ASA groups 3 and 4). Anesth Intensive Care 1999; 27: 477-80. 53. Franklin QJ. Sudden death after typhoid and Japanese encephalitis vaccination in a male taking pseudoephedrine. Mil Med 1999; 164: 157-9.

The treatment lasted for 24 weeks. Metrifonate improved a wide range of symptoms across all four clinical domains of Alzheimer's disease in a dosedependent manner, and was well tolerated at both doses studied. One patient withdrew from the study during the high-dose loading phase owing to cholinergic effects, resulting in muscle weakness. Metrifonate was also associated with a slight gradual lowering of hemoglobin, hematocrit, and erythrocyte count in both groups during first 12 weeks. These were non-progressive, stabilized over the 6-month treatment period, and hence were not considered to be clinically relevant.

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