Download Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser, PDF

By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

This quantity represents the lawsuits of the 5th Congress of the overseas Society of Ocular Toxicology (ISOT), which used to be held on the Grove Park lodge and inn in Asheville, North Carolina, October 13-17, 1996. we're extremely joyful to offer this quantity to the ophthalmic group, particularly people with an important curiosity in ocular toxicol­ ogy. The 5th Congress was once constructed round issues with regards to ocular drug metabolism, the ocular pathophysiological results of nitric oxide, govt matters in terms of using replacement tools for toxicity checking out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo versions in addition to diverse animal types. the end result of this congress, embodied during this quantity, is a contribution to the methodologies presently hired or less than improvement and to numerous drug or actual results on diversified ocular tissues. whereas the point of interest of this lawsuits is on ocular results of gear or different fabrics, the various contributions care for themes that experience a wider curiosity. The workshop about the use of alternative version platforms and the alternative of the easiest animal version for drug checking out covers quite a lot of pursuits that ex­ has a tendency a ways past particular ocular results. this is often very true within the region of different tools and within the collection of the easiest animal version for exam of other illness entities.

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18 M. L. Schwartzman 70. Stoltz RA, Conners MS, Dunn MW, Schwartzman ML. Effect of metabolic inhibitors on arachidonic acid metabolism in the corneal epithelium: Evidence for cytochrome P450 mediated reactions. J Ocul Pharm 1994; 10:307-317. 71. Yamamoto S, Nishimura M, Conners MS, Stoltz RA, Falck JR, Chauhan K, Laniado-Schwartzman M. Oxidation and keto reduction of 12-hydroxy-5,8,10,14-eicosatrienoic acids in bovine corneal epithelial microsomes. Biochim Biophys Acta 1994; 1210:217-225. 72. Conners MS, Stoltz RA, Laniado-Schwartzman M.

CS03 H = protein bound cysteine released as cysteic acid. GS0 3H =protein bound GSH released as glutathione sulfonic acid. G + C =GS03 H + CS0 3H. Cor =cortex, Nuc =nucleus 36 M. F. Lou Table 5. 2 "'Data is expressed as ~lmoles/gram dry lens weight. WS = water soluble proteins, WI ::;: water insoluble proteins. C/G = CS0 3 H/GS0 3H. CS0 3 H = protein bound cysteine released as cysteic acid. GS0 3H = protein bound GSH released as glutathione sulfonic acid. WS/WI = dry weight of the water soluble fraction I dry weight of the water insoluble fraction.

Each data point represents four lenses which were pooled and processed for GS0 3H and cysteic acid quantitation. M. Protein-Thiol Mixed Disulfides and Thioltransferase in the Lens 37 shows a reciprocal relationship to the gradually increased PSSG. GSSG however has not been detected either in the lens or in the culture media. The formation of PSSG is also shown as a function of time (Figure 7). PSSC level remains unchanged under both the time-dependent and the HP2 concentration-dependent experimental conditions.

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