By Donata Vercelli MD (auth.), Judah A. Denburg MD, FRCP(C) (eds.)
In allergic reaction and Allergic ailments: the recent Mechanisms and Therapeutics, a exceptional overseas panel of researchers and clinicians overview the most recent findings at the mobile and molecular foundations of allergic ailments, quite these of the airway, epidermis, and bowel. the major themes handled span the variety from epidemiology and the mechanisms of irritation, to signaling in pathogenesis and allergies. every one contributor treats the pathophysiology of hypersensitive reaction in quite a few organ-based illnesses and syndromes, emphasizing vital new findings from mobile and molecular biology that light up those ailments, but in addition exhibit vital leads for the improvement of novel medications and healing innovations.
hypersensitivity and Allergic illnesses: the hot Mechanisms and Therapeutics highlights the interface among easy and medical technology in allergic illness. Its updated, clinically correct technique constitutes the recent average wisdom base in medical immunology and hypersensitivity, not just for experts, but in addition for internists, for scientists learning the mobile and molecular biology of irritation and immunity, and for researchers serious about drug discovery and therapeutics. Authoritative and well timed, hypersensitivity and Allergic ailments is obviously the latest fundamental new source for all physicians and investigators looking a deeper figuring out of allergic reaction in either its easy and scientific facets.
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Extra resources for Allergy and Allergic Diseases: The New Mechanisms and Therapeutics
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J Exp Med 177:1209-1213. 22. Fuleihan R, Ramesh N, Loh R, Jabara H, Rosen RS, Chatila T, Fu SM, Stamenkovic I, Geha RS (1993) Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc Natl Acad Sci USA 90:2170-2173. 23. Di Santo JP, Bonnefoy JY, Gauchat JF, Fischer A, De Saint Basile G (1993) CD40 ligand mutations in x-linked immunodeficiency with hyper-IgM. Nature 361:541-543. 24. Allen RC, Armitage RJ, Conley ME, Rosenblatt H, Jenkins NA, Copeland NG, Bedell MA, Edelhoff S, Disteche CM, Simoneaux DK, Fanslow BC, Belmont J, Spriggs MK (1993) CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome.
YI24D, binds with high affinity to the IL-4R a-chain without significant receptor activation (71 ,217). YI24D blocks the biological activities of both IL-4 and IL-13. YI24D inhibited in a dose-dependent manner IgG4 and IgE synthesis induced by optimal concentrations ofIL-4 or IL-13 in vitro (75). YI24D was added at 20-50-fold excess as com- Chapter 2 / Cytokines and IgE Regulation 29 pared to IL-4 or IL-13. Y124D effectively inhibited IL-4- and IL-13induced B-cell proliferation and germline E transcription (214).