By Hans-Peter Lipp
Containing the newest findings at the toxicity of quite a lot of chemotherapeutic brokers, this up to date reference bargains specialist analyses at the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds. Anticancer Drug Toxicity ·explores healing drug tracking (TDM) as a style of maximizing the efficacy, and minimizing the risks, of chemotherapy ·presents an unlimited volume of medical pharmacokinetic information on cytostatic medications ·offers a entire type of toxicity styles linked to using cytotoxic medications ·analyzes the pharmacokinetics of alkylating brokers, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and different cytotoxic brokers ·highlights the pharmacogenetics of 6-mercaptopurine and its scientific value ·explicates toxicity on the subject of the lungs, kidneys, center, and gonads ·examines problems as a result of asparaginase arrangements ·reviews kinds of secondary malignancy equivalent to leukemias, ovarian melanoma, testicular melanoma, breast melanoma, secondary reliable neoplasias, and Hodgkin's disorder ·clarifies the knowledge of toxicity as a vital aspect in supportive administration of melanoma remedy ·and extra! An tremendously useful advisor for daily medical perform, in addition to a resource of thought for extra study within the box, Anticancer Drug Toxicity is a useful reference for scientific and clinical oncologists; medical institution, business, and medical pharmacologists and pharmacists; toxicologists; pharmaceutical chemists; radiologists; and graduate and clinical institution scholars in those disciplines.
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Extra resources for Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics
Problems of compliance with drug treatment: new solutions? Pharm J 245: 213–5, 1990. 20. Benet LZ, Oie SS, Schwartz JB. Design and optimization of dosage regimens; pharmacokinetic data. In: Goodman & Gilman’s The Pharmacological Basis of Therapeutics, Ninth Edition. Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. New York: McGraw-Hill, 1996, p. 1729. 21. Maenpaa H, Manninen V, Heinonen OP. Compliance with medication in the Helsinki Heart Study. Eur J Clin Pharmacol 42: 15–19, 1992.
4). As new approaches in computer simulation of clinical trials develop, the construct of therapeutic coverage will probably attract widened attention, because it allows focusing on the periods of inadequate drug action and their clinical correlates. Use of the therapeutic coverage concept serves to emphasize, however, how little we know about the post-dose duration of action of widely used drugs. One can only hope that appropriate studies to define this key parameter will become standard in new drug development.
As early as 1957, when the methodology of randomized trials was still in its childhood, Dixon et al. perceived and described the problems encountered with partial compliance in clinical trials3: ‘Many chemotherapy trials based on unsupervised oral medication have probably been built on very unsure foundations. However carefully they were controlled statistically and scientifically, Drug Regimen Compliance: Issues in Clinical Trials and Patient Management. -M. A. Meyer. 1999 John Wiley & Sons Ltd.